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US 33 E to I-77 S to Columbia SC
I-26 E to I-95 S
to Jacksonville Fl
I-295 S/W to I-10 W to 301 S to !-75 S to Ocala FL
12 hrs 15 minutes
u could pick up US 321 @ columbia on down to I-95S
and 768 miles but 13 hrs 45 minutes