1 Answer

No. It is an antidepressant with many side effects (listed below) but sleepiness isn’t one of them:  

Hives inability to sit still itching restlessness skin rash Less common Chills or fever joint or muscle pain Rare Anxiety cold sweats confusion convulsions (seizures) cool pale skin diarrhea difficulty with concentration drowsiness dryness of the mouth excessive hunger fast or irregular heartbeat headache increased sweating increased thirst lack of energy mood or behavior changes overactive reflexes purple or red spots on the skin racing heartbeat shakiness or unsteady walk shivering or shaking talking, feeling, and acting with excitement and activity you cannot control trouble with breathing unusual or incomplete body or facial movements unusual tiredness or weakness Incidence not known Abdominal or stomach pain agitation back or leg pains bleeding gums blindness blistering, peeling, or loosening of the skin bloating blood in the urine or stools bloody, black, or tarry stools blue-yellow color blindness blurred vision chest pain or discomfort clay-colored stools constipation continuing vomiting cough or dry cough dark urine decreased urine output decreased vision depression difficulty with breathing difficulty with swallowing dizziness or lightheadedness eye pain fainting fast, pounding, or irregular heartbeat or pulse general body swelling high fever hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue hostility indigestion irregular or slow heart rate irritability large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs light-colored stools loss of appetite loss of bladder control muscle twitching nausea nightmares no blood pressure or pulse noisy breathing nosebleeds pain in the ankles or knees painful, red lumps under the skin, mostly on the legs pains in the stomach, side, or abdomen, possibly radiating to the back pinpoint red spots on the skin rapid weight gain red or irritated eyes red skin lesions, often with a purple center redness, tenderness, itching, burning, or peeling of the skin severe muscle stiffness severe sleepiness slurred speech sore throat sores, ulcers, or white spots on the lips or in the mouth stopping of heart sudden shortness of breath or troubled breathing sudden weakness in the arms or legs sudden, severe chest pain swelling of the face, ankles, or hands swollen or painful glands thoughts of killing oneself tightness in the chest tiredness twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs unconsciousness unpleasant breath odor unusual bleeding or bruising unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness unusually pale skin use of extreme physical or emotional force vomiting of blood yellow eyes or skin Some of the side effects that can occur with fluoxetine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional: More common Decreased appetite Less common or rare Abnormal dreams breast enlargement or pain change in sense of taste changes in vision feeling of warmth or heat flushing or redness of the skin, especially on face and neck frequent urination hair loss increased appetite increased sensitivity of the skin to sunlight menstrual pain stomach cramps, gas, or pain unusual secretion of milk, in females weight loss yawning Incidence not known Cracks in the skin loss of heat from the body painful or prolonged erections of the penis scaly skin swelling of the breasts or breast soreness in both females and males unusual milk production For Healthcare Professionals Applies to fluoxetine: compounding powder, oral capsule, oral delayed release capsule, oral solution, oral tablet General The most common side effects that have been associated with the discontinuation of placebo-controlled clinical trials were anxiety, nervousness, nausea, rash, pruritus, insomnia, asthenia, and headache. The side effect profile appears generally similar between adults, children, and adolescents. Treatment-emergent side effects reported in pediatric patients that were reported at an incidence of at least 2% or more for fluoxetine and greater than placebo included thirst, hyperkinesia, agitation, personality disorder, epistaxis, urinary frequency, and menorrhagia. The most common side effect associated with treatment discontinuation in children and adolescents was mania/hypomania.[Ref] Psychiatric Antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. An increased risk of suicidal thinking and behavior in children, adolescents, and young adults (aged 18 to 24 years) with major depressive disorder (MDD) and other psychiatric disorders has been reported with short-term use of antidepressant drugs. Adult and pediatric patients receiving antidepressants for MDD, as well as for psychiatric and nonpsychiatric indications, have reported symptoms that may be precursors to emerging suicidality, including anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania, and mania. Causality has not been established.[Ref] Very common (10% or more): Anxiety, insomnia, nervousness Common (1% to 10%): Abnormal dreams, disturbance in attention, emotional lability, feeling abnormal, restlessness, sleep disorder, tension, thinking abnormal Uncommon (0.1% to 1%): Akathisia, apathy, bruxism, depersonalization, elevated mood, euphoria, hostility, intentional overdose, manic reaction, neurosis, paranoid reaction, personality disorder, psychomotor hyperactivity, psychosis, suicide attempt Rare (less than 0.1%): Agitation, antisocial reaction, delusions, hallucinations, hypomania, intentional injury, mania, panic attacks, stupor Frequency not reported: Dysphemia, suicidal thoughts and behavior Postmarketing reports: Confusion, violent behaviors[Ref] Nervous system Very common (10% or more): Dizziness, headache, somnolence, tremor Common (1% to 10%): Amnesia, paresthesia, taste perversion Uncommon (0.1% to 1%): Abnormal gait, acute brain syndrome, ataxia, balance disorder, CNS depression, CNS stimulation, dyskinesia, hyperkinesia, hypesthesia, hypertonia, incoordination, migraine, myoclonus, neuralgia, neuropathy, seizures, syncope, vascular headache Rare (0.01% to 0.1%): Abnormal EEG, cerebral embolism, cerebral ischemia, circumoral paresthesia, convulsion, decreased reflexes, dysarthria, dystonia, extrapyramidal syndrome, foot drop, hyperesthesia, neuritis, paralysis, taste loss Very rare (less than 0.01%): Serotonin syndrome (neuroleptic malignant syndrome-like effects) Postmarketing reports: Cerebrovascular accident, memory impairment, movement disorders, oculogyric crisis, tardive dyskinesia[Ref] One retrospective study of 23 outpatients with Parkinson's disease treated with 40 mg of fluoxetine a day reported that three patients experienced worsening of parkinsonism, two patients experienced improvement of parkinsonism, and 18 patients experienced no change. Another small study reported a series of four patients who experienced worsening of parkinsonism during treatment with fluoxetine. Potentially life-threatening serotonin syndrome has been reported with SSRIs and SNRIs as monotherapy, but particularly with concomitant use of other serotonergic drugs and drugs that impair the metabolism of serotonin. A number of case reports have implicated fluoxetine in causing seizures. Twelve of 6000 patients experienced convulsions during pre-marketing testing. A case of dose-dependent exacerbation of preexisting, mild restless legs syndrome (which ultimately required discontinuation of fluoxetine) has been reported.[Ref] Cardiovascular One placebo-controlled study has suggested that fluoxetine has no effects on intraventricular conduction. Other case reports have suggested that fluoxetine may rarely provoke dysrhythmias. Other conflicting case reports have suggested that fluoxetine may have a propensity to provoke and alleviate vasoconstriction. Several cases of unexpected death occurring shortly after initiation of fluoxetine therapy have been reported in elderly patients with multiple medical problems. In one case report, QTc prolongation and torsades de pointes developed in an elderly woman 6 months after starting therapy with fluoxetine 20 mg daily. The QTc interval returned to normal following discontinuation of fluoxetine. Four additional cases suggesting fluoxetine associated QTc prolongation or torsades de pointes have been reported.[Ref] Common (1% to 10%): Chest pain, flushing, hypertension, palpitations, vasodilatation Uncommon (0.1% to 1%): Angina pectoris, arrhythmia, congestive heart failure, generalized edema, hypotension, myocardial infarct, peripheral edema, postural hypotension Rare (less than 0.1%): Bradycardia, extrasystoles, heart block, pallor, peripheral vascular disorder, phlebitis, shock, thrombophlebitis, thrombosis, vasculitis, vasospasm, ventricular extrasystoles, ventricular fibrillation Postmarketing reports: Atrial fibrillation, heart arrest, QT-interval prolongation and ventricular arrhythmia including torsades de pointes[Ref] Gastrointestinal A study of 26,005 antidepressant users has reported 3.6 times more upper GI bleeding episodes with the use of SSRIs relative to the population who did not receive antidepressant medications. Upper gastrointestinal tract bleeding was observed in 3.9 times more frequently in patients receiving fluoxetine.[Ref] Very common (10% or more): Diarrhea, dry mouth, nausea Common (1% to 10%): Abdominal pain, constipation, dyspepsia, flatulence, increased appetite, vomiting Uncommon (0.1% to 1%): Aphthous stomatitis, buccoglossal syndrome, cholelithiasis, colitis, dysphagia, eructation, esophagitis, gastritis, gastroenteritis, glossitis, gum hemorrhage, hyperchlorhydria, increased salivation, melena, mouth ulcerations, stomach ulcer, stomatitis, thirst Rare (less than 0.1%): Acute abdominal syndrome, biliary pain, bloody diarrhea, cholecystitis, duodenal ulcer, enteritis, esophageal pain, esophageal ulcer, fecal incontinence, gastrointestinal hemorrhage, hematemesis, intestinal obstruction, pancreatitis, peptic ulcer, salivary gland enlargement, stomach ulcer hemorrhage, tongue edema Postmarketing reports: Gastrointestinal bleeding[Ref] Metabolic Numerous cases of hyponatremia have been reported following treatment with an SSRI. Risk factors for the development of SSRI associated hyponatremia including advanced age, female gender, concomitant use of diuretics, low body weight, and lower baseline serum sodium levels have been identified. Hyponatremia tends to develop within the first few weeks of treatment (range 3 to 120 days) and typically resolves within 2 weeks (range 48 hours to 6 weeks) after therapy has been discontinued with some patients requiring treatment. The proposed mechanism for the development of hyponatremia involves the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) via release of antidiuretic hormone. Decreased weight gain has been observed in association with the use of fluoxetine in children and adolescent patients.[Ref] Very common (10% or more): Anorexia Common (1% to 10%): Weight loss Uncommon (0.1% to 1%): Decreased appetite, dehydration, gout, hypocholesteremia, hyperlipemia, hypokalemia Rare (less than 0.1%): Alcohol intolerance, creatine phosphokinase increased, diabetes mellitus, hyperkalemia, hyperuricemia, hypocalcemia, hyponatremia Postmarketing reports: Hypoglycemia[Ref] Other Very common (10% or more): Fatigue (including asthenia) Common (1% to 10%): Accidental injury, chills, ear pain, feeling jittery, fever, infection, pain, tinnitus Uncommon (0.1% to 1%): Face edema, feeling hot/cold, malaise, vertigo Rare (less than 0.1%): Deafness, hyperacusis, hypothermia Frequency not reported: Mucosal hemorrhage Postmarketing reports: Malignant hyperthermia[Ref] Genitourinary Common (1% to 10%): Decreased libido, ejaculation disorder, erectile dysfunction, gynecological bleeding, impotence, urinary frequency Uncommon (0.1% to 1%): Abortion, albuminuria, amenorrhea, anorgasmia, breast enlargement, breast pain, cystitis, dysuria, female lactation, fibrocystic breast, hematuria, impaired urination, Increased libido, leukorrhea, menorrhagia, metrorrhagia, nocturia, pelvic pain, polyuria, sexual dysfunction (occasionally persisting after treatment discontinuation), urinary incontinence, urinary retention, urinary urgency, vaginal hemorrhage Rare (less than 0.1%): Breast engorgement, galactorrhea, glycosuria, hypomenorrhea, kidney pain, oliguria, priapism, uterine fibroids, uterine hemorrhage Postmarketing reports: Enlarged clitoris, gynecomastia, vaginal bleeding[Ref] Urinary retention and galactorrhea have been reported with other SSRIs. The estimates of the incidence of untoward sexual experience and performance may underestimate their actual incidence, partly because patients and physicians may be reluctant to discuss this issue. In placebo-controlled clinical trials ejaculation disorder (primarily ejaculation delay) was reported as a treatment-emergent side effect at an incidence of 6% and at least twice the incidence in placebo-treated male patients.[Ref] Dermatologic Common (1% to 10%): Pruritus, rash, sweating, urticaria Uncommon (0.1% to 1%): Acne, alopecia, cold sweat, contact dermatitis, ecchymosis, eczema, increased tendency to bruise, maculopapular rash, skin discoloration, skin ulcer Rare (less than 0.1%): Angioedema, furunculosis, hirsutism, petechia, photosensitivity reaction, psoriasis, purpura, purpuric rash, seborrhea Postmarketing reports: Epidermal necrolysis, erythema multiforme, erythema nodosum, exfoliative dermatitis, Stevens Johnson syndrome, thrombocytopenic purpura[Ref] Approximately 3% of treated patients have been reported to develop a skin reaction.[Ref] Endocrine Uncommon (0.1% to 1%): Hypothyroidism Rare (less than 0.1%): Diabetic acidosis, hyperprolactinemia Postmarketing reports: Inappropriate secretion of antidiuretic hormone[Ref] Hematologic Uncommon (0.1% to 1%): Anemia Rare (less than 0.1%): Blood dyscrasia, hypochromic anemia, leukopenia, lymphedema, lymphocytosis, thrombocythemia, iron deficiency anemia Very rare (less than 0.01%): Thrombocytopenia Postmarketing reports: Aplastic anemia, eosinophilia, immune-related hemolytic anemia, pancytopenia[Ref] Hepatic Uncommon (0.1% to 1%): Abnormal liver function tests Rare (less than 0.1%): Alkaline phosphatase increased, hepatitis, liver fatty deposit, SGPT increased Postmarketing reports: Aggravation of hepatic damage, cholestatic jaundice, hepatic failure/necrosis, idiosyncratic hepatitis[Ref] Hypersensitivity Common (1% to 10%): Allergic reaction Rare (less than 0.1%): Anaphylactoid reaction, serum sickness[Ref] Immunologic Common (1% to 10%): Flu syndrome Uncommon (0.1% to 1%): Herpes zoster[Ref] Musculoskeletal Epidemiological studies, primarily in patients aged 50 years or older, have shown an increased risk of bone fractures in patients receiving SSRIs or TCAs.[Ref] Common (1% to 10%): Arthralgia, twitching Uncommon (0.1% to 1%): Arthritis, bone pain, bursitis, leg cramps, tenosynovitis Rare (less than 0.1%): Arthrosis, chondrodystrophy, myasthenia, myopathy, myositis, osteomyelitis, osteoporosis, rheumatoid arthritis Frequency not reported: Myalgia[Ref] Ocular Common (1% to 10%): Abnormal vision, vision blurred Uncommon (0.1% to 1%): Conjunctivitis, dry eyes, mydriasis, photophobia Rare (less than 0.1%): Blepharitis, diplopia, exophthalmos, glaucoma, iritis, scleritis, strabismus, visual field defect Postmarketing reports: Cataract, optic neuritis[Ref] Renal Rare (less than 0.1%): BUN increased Postmarketing reports: Kidney failure[Ref] Respiratory Very common (10% or more): Pharyngitis, rhinitis Common (1% to 10%): Epistaxis, yawn Uncommon (0.1% to 1%): Asthma, dyspnea, hiccup, hyperventilation Rare (less than 0.1%): Apnea, atelectasis, decreased cough, emphysema, hemoptysis, hypoventilation, hypoxia, larynx edema, lung edema, parosmia, pneumothorax, stridor, Frequency not reported: pulmonary events (inflammatory processes of varying histopathology and/or fibrosis) Postmarketing reports: Eosinophilic pneumonia, pulmonary embolism, pulmonary hypertension[Ref] References 1. 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Promoted by BP More about fluoxetine Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Espanol 490 Reviews - Add your own review/rating Consumer resources Fluoxetine Fluoxetine delayed-release capsules Fluoxetine solution Fluoxetine (Advanced Reading) Other brands: Prozac, Sarafem, Rapiflux, Prozac Weekly, More (1) » Professional resources Fluoxetine Hydrochloride (AHFS Monograph) More (5) » Related treatment guides Anxiety and Stress Borderline Personality Disorder Depression Hot Flashes Trichotillomania More (16) » Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. 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Sign In or Register Related Information Availability Rx Prescription only Pregnancy Category C Risk cannot be ruled out CSA Schedule N Not a controlled drug Approval History Calendar Drug history at FDA Allergies ReviewsAverage User Rating 490 User Reviews 7.9 Rate it! Drug Class Selective serotonin reuptake inhibitors (SSRIs) Related Questions & Answers I been off Fluoxetine approx 7months. How long does this drug stay in your system after you quit? can you take fluoxetine and celexa together? Fluoxetine for a month, I want to come off if. How should I do this? i got fluoxetine (prozac) for panic attacks, has it caused heart problems for anyone? Will side effects go away or become more tolerable with time? Read more questions... Fluoxetine Images Fluoxetine Hydrochloride 20 mg Fluoxetine 20 mg Fluoxetine Hydrochloride 20 mg Fluoxetine 20 mg View all 116 images SupportAbout Drugs.comYour Privacy Advertise With Us Frequently Asked Questions Ask a Question Content Submissions Mobile Apps About Drugs.com Contact Us Sitemap Follow:Google+FacebookTwitterYouTubeRSS Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex® (updated Jan 7th, 2015), Cerner Multum™ (updated Jan 15th, 2015), Wolters Kluwer™ (updated Jan 14th, 2015) and others. To view content sources and attributions, refer to our editorial policy. Copyright © 2000-2015 Drugs.com. All rights reserved. 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